The Hotel Bethlehem is a 125-room hotel located in Bethlehem, Pennsylvania. The hotel, which was built in 1922, is a member of the Historic Hotels of America and was built in a Beaux Arts style. It is listed on the National Register of Historic Places as part of the Central Bethlehem Historic District, which includes 165 contributing buildings. It replaced a hotel that was converted from a general store in 1822.